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Prof. A.R. Thierry has contributed to cirDNA applications in clinical and basic research, coordinating the first prospective blinded multicenter studies to offer clinical validation of plasma analysis for detecting mutations in oncology, and demonstrating the clinical utility of using cirDNA analysis in digestive oncology. His team has also been engaged in basic research focused on cirDNA structure and function, has pioneered work on cirDNA fragmentation and its application in cancer screening, has shown the presence in blood of circulating functional cell-free mitochondria, and recently demonstrated cirDNA association with NETs production in cancer and COVID-19 disease.

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